It is a safe and effective treatment for many bacterial, fungal and protozoal in the aquarium The usual dose of 250 mg per 40 L (10 U.S. gallons), but this dose may be increased up to 4 times. Carbon easily removable and does not deteriorate with the nitrification process. For use in fresh water aquariums or marine. Sulfaplex treat parasitic infections, fungal and bacterial infections.